The Protein Dynamics Workshop

The workshop is a forum for teaching, presenting and discussing results from the application of state-of-the-art theoretical/computational approaches and experimental techniques to studying protein dynamics.

The activities of the 2024 Les Houches - Telluride Protein Dynamics Workshop will place a particular focus on the (1) presentation of new results and outstanding challenges in the field of protein dynamics and (2) comparison of theoretical and computational predictions with the results of experimental studies.

Specific topics of focus that will be addressed in pedagogical lectures and research presentations include:

• molecular dynamics simulations of globular, intrinsically disordered and membrane proteins
• developments of computational approaches able to access long time scales
• ultra-fast protein dynamics and their interpretation using state-of-the-art quantum mechanical and molecular dynamics simulations, with a focus on time-resolved x-ray scattering of protein dynamics in photolysis, light-harvesting, and ligand binding
• characterization of intrinsically disordered proteins using single-molecule spectroscopy, NMR and computation
• quantitative analysis of contributions of dynamics and of entropy to the thermodynamics of protein-protein and protein-ligand interactions through comparison of simulation and NMR experiments
• solvent dynamics and characterization of other effects of the environment of a protein (water, membrane, and crowded environment of the cell), using a variety of scattering techniques and MD simulations
• using machine learning in the analysis of experimental data as well as for augmenting numerical simulations

Since 2014, the Les Houches – Telluride Workshop on Protein Dynamics builds on the reputation and tradition of the highly successful Protein Dynamics Workshop at the Telluride Science Research Center (TSRC; Colorado, USA). The latter, "TSRC Protein Dynamics Workshop", has been held biennially in the odd calendar years since 1999 and has traditionally included scientists using computational and experimental approaches to address fundamental problems in protein dynamics. The participation has largely been restricted to junior and senior faculty, with very limited participation of graduate students and postdoctoral research scientists. The Les Houches – Telluride Workshop on Protein Dynamics will continue in the tradition of the TSRC meeting, while expanding the scope and impact in two important ways: a) the majority of participants will be from Europe and b) the workshop admits 30 graduate students and postdoctoral scientists. We continue our partnership with the TSRC (now called Telluride Science), which allows us to gain visibility in the North American community.

design by Fede Napoli